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Related Experiment Videos

CBS domains: structure, function, and pathology in human proteins.

Sofie Ignoul1, Jan Eggermont

  • 1Laboratory of Physiology, K.U. Leuven, Campus Gasthuisberg O&N, Herestraat 49, B-3000 Leuven, Belgium.

American Journal of Physiology. Cell Physiology
|November 9, 2005
PubMed
Summary

Cystathionine-beta-synthase (CBS) domains are conserved protein structures found across life. Recent findings suggest these domains act as sensors for intracellular metabolites like ATP, influencing protein function.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Structural Biology

Background:

  • The cystathionine-beta-synthase (CBS) domain is a conserved protein module present in diverse organisms and protein types.
  • CBS domains often appear in tandem repeats and are implicated in various cellular functions, including metabolism, signaling, and transport.
  • Mutations in CBS domains are linked to several human hereditary diseases, highlighting their clinical significance.

Purpose of the Study:

  • To elucidate the precise function of CBS domains and their impact on protein structure and activity.
  • To investigate the proposed role of CBS domains as sensors of intracellular metabolites.

Main Methods:

  • Review of crystallographic studies on bacterial CBS domains.
  • Analysis of literature on the functional roles and mutations associated with CBS domains in various proteins.

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  • Integration of recent experimental findings on ligand binding by CBS domains.

    • Main Results:

    • CBS domains form intramolecular dimeric structures, as shown in bacterial studies.
    • CBS domains are found in proteins with diverse functions, including enzymes, kinases, and ion channels.
    • Recent evidence indicates CBS domains bind adenosine-containing ligands such as ATP, AMP, and S-adenosylmethionine.

    Conclusions:

    • CBS domains are evolutionarily conserved and functionally versatile protein modules.
    • The ability of CBS domains to bind adenosine-based metabolites supports their role as cellular sensors.
    • Understanding CBS domain function is crucial for deciphering the mechanisms behind associated hereditary diseases.