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Related Experiment Videos

Sensory suppression during feeding.

H Foo1, Peggy Mason

  • 1Department of Neurobiology, University of Chicago, IL 60637, USA.

Proceedings of the National Academy of Sciences of the United States of America
|November 9, 2005
PubMed
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Rats suppress pain responses during feeding by altering brainstem pain pathways. This research reveals how the brain prioritizes essential behaviors like eating over protective withdrawal reflexes.

Area of Science:

  • Neuroscience
  • Behavioral Biology
  • Pain Research

Background:

  • Feeding and withdrawal are vital survival behaviors.
  • Painful stimuli during feeding create a conflict between these essential behaviors.
  • Pain suppression offers a strategy to resolve this conflict and optimize feeding.

Purpose of the Study:

  • To investigate if rats can suppress pain responses while feeding.
  • To explore the neural mechanisms underlying sensory suppression during feeding.
  • To determine the role of brainstem pain-modulatory neurons in this process.

Main Methods:

  • Rats were subjected to noxious heat stimuli during feeding.
  • Neural activity of brainstem pain-modulatory neurons (ON and OFF cells) was recorded.

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  • The effect of pre-activating or inhibiting these neurons on pain responses was examined.
  • Inactivation of specific brainstem regions was performed.

    • Main Results:

    • Motor withdrawal responses to pain were significantly delayed or absent during feeding.
    • Feeding inhibited pain-facilitatory ON cells and excited pain-inhibitory OFF cells in the brainstem.
    • Altering the activity of ON and OFF cells before painful stimuli affected feeding behavior.
    • Brainstem inactivation abolished pain suppression during feeding.

    Conclusions:

    • Brainstem pain-modulatory neurons play a critical role in suppressing motor reactions to pain during homeostatic behaviors like feeding.
    • The descending pain control system actively modulates sensory processing to facilitate essential activities.
    • This provides insight into the neural basis of behavioral prioritization under competing demands.