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Nesiritide for pulmonary arterial hypertension with decompensated cor pulmonale
Martha S Kingman1, Brenda S Thompson, Trixie Newkirk
1Pulmonary Hypertension Group, Pulmonary Hypertension Clinic, Cardiovascular Institute, St. Paul University Hospital, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
Abstract:
Pulmonary arterial hypertension complicated by decompensated cor pulmonale is a challenging clinical problem with few effective therapeutic options. B-type natriuretic peptide is a pluripotent hormone that promotes diuresis and natriuresis, vasodilates systemic and pulmonary vessels, and reduces circulating levels of endothelin and aldosterone. It may represent a possible therapeutic strategy for decompensated cor pulmonale in the same manner that it is used to treat decompensated left heart failure. The authors report their experience with B-type natriuretic peptide as adjunctive therapy for pulmonary arterial hypertension complicated by decompensated cor pulmonale. A detailed case report is presented followed by the evaluation of a series of 11 cases occurring in eight patients from December 2002 through April 2004.
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