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Updated: Aug 15, 2026

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
Published on: August 23, 2024
[PPARgamma agonists--antidiabetics with positive effects on cardiovascular risk?]
1Nyremedisinsk avdeling, Ullevål universitetssykehus, og Fakultetsdivisjon Ullevål, Universitetet i Oslo, 0407 Oslo. ingrid.os@medisin.uio.no
Introduction:
Peroxisome proliferator-activated receptor agonists are used as an antidiabetic drug with particular effect on insulin sensitivity.
Material And Methods:
This paper is based upon own literature and a Medline search.
Results And Interpretation:
The drug improves insulin sensitivity, but has several cardiovascular effects as well. Blood pressure, serum lipids, endothelial function, inflammation and growth of smooth muscle are all modulated by these agonists. This group of drugs shows constant antiatherosclerotic properties. Larger clinical studies will give the answer whether this treatment can reduce micro- and macro-vascular complications in diabetes.
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