Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Surgery for hemophilia in developing countries.

Vikram Mathews1, Auro Viswabandya, Shoma Baidya

  • 1Department of Haematology, Christian Medical College, Vellore, Tamil Nadu, India.

Seminars in Thrombosis and Hemostasis
|November 9, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Probiotics: multifunctional microorganisms for human health and biotechnological applications.

Frontiers in microbiology·2026
Same author

AI in multi-omics analysis of type 2 diabetes.

Progress in molecular biology and translational science·2026
Same author

Seventh Åland Island Meeting on von Willebrand Disease.

Haemophilia : the official journal of the World Federation of Hemophilia·2026
Same author

Exploring the oral microbiome: from traditional techniques to advanced omics and databases.

Antonie van Leeuwenhoek·2026
Same author

A Second Factor VIIIa Mimetic for Hemophilia A.

The New England journal of medicine·2026
Same author

Response to hemophilia B gene therapy based on adenoassociated virus serotype 5 antibody status.

Research and practice in thrombosis and haemostasis·2026

Low-dose factor concentrate prophylaxis is effective for patients with hemophilia (PWH) undergoing surgery in developing countries. This approach optimizes resource use without significantly increasing hemorrhage risk.

Area of Science:

  • Hematology
  • Global Health
  • Surgical Management

Background:

  • Surgical care for patients with hemophilia (PWH) is challenging in developing nations due to limited factor concentrate availability.
  • International guidelines for factor concentrate prophylaxis during surgery are often impractical in resource-limited settings.
  • Existing recommendations lack data from large clinical trials and do not define safe lower limits for prophylaxis.

Purpose of the Study:

  • To evaluate the efficacy and safety of a lower-dose factor concentrate prophylaxis regimen for surgical patients with hemophilia in a developing country.
  • To provide a framework for establishing practical guidelines for hemophilia care in resource-limited settings.

Main Methods:

  • Retrospective analysis of surgical interventions in patients with hemophilia (PWH) at a tertiary referral center in India.

Related Experiment Videos

  • Comparison of an established low-dose factor concentrate prophylaxis regimen with international recommendations.
  • Assessment of factor consumption and risk of delayed hemorrhage.

    • Main Results:

    • The institution's low-dose factor concentrate prophylaxis protocols were found to be effective for surgical patients with hemophilia.
    • Factor consumption was reduced by approximately one-third compared to standard international guidelines.
    • No significantly increased risk of delayed hemorrhage was observed with the low-dose regimen.

    Conclusions:

    • Lower-dose factor concentrate prophylaxis regimens can be safely and effectively implemented for surgical patients with hemophilia in developing countries.
    • This approach allows for optimal utilization of limited factor concentrate resources.
    • The findings support the development of tailored guidelines for hemophilia management in resource-limited settings.