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Efficacy of nebulized furosemide in children with moderate attack of asthma

M Alshehri1, T Almegamesi, A Alfrayh

  • 1Department of Pediatrics, College of Medicine, King Khalid University, Abha, Kingdom of Saudi Arabia. fariss2000@yahoo.com

West African Journal of Medicine
|November 10, 2005
PubMed

Insights

Nebulized furosemide showed comparable efficacy to albuterol in treating moderate asthma exacerbations in children. Combining both drugs significantly improved peak flow rate without adverse effects.

Area of Science:

  • Pediatric Pulmonology
  • Clinical Pharmacology
  • Respiratory Medicine

Background:

  • Bronchodilators are standard asthma treatments.
  • Alternative therapies are needed for patients with adverse reactions to bronchodilators.

Purpose of the Study:

  • To evaluate the effectiveness of nebulized furosemide in pediatric patients experiencing moderate asthma exacerbations.

Main Methods:

  • A double-blind, randomized controlled trial was conducted with three groups of children.
  • Group A received nebulized albuterol, Group B received nebulized furosemide, and Group C received both.
  • Pulmonary function, peak flow, respiratory rate, oxygen saturation, and clinical scores were assessed pre- and post-treatment.

Main Results:

  • No significant differences in FEV1 or FVC improvements were observed among the three groups.
  • Peak expiratory flow rate (PEFR) significantly increased in the combination group (albuterol and furosemide).
  • Respiratory rate, SaO2, and clinical scores showed no significant differences across groups.

Conclusions:

  • Combining furosemide with albuterol significantly enhanced peak flow rate in children with moderate asthma exacerbations.
  • Nebulized furosemide demonstrated comparable efficacy to albuterol, with no significant adverse effects noted for any treatment group.
Abstract

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