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Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease
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Evaluation of right and left ventricular function using pulsed-wave tissue Doppler echocardiography in patients with

F Kosar1, I Sahin, N Turan

  • 1Department of Cardiology, Inonu University, Malatya, Turkey.

Journal of Endocrinological Investigation
|November 10, 2005
PubMed

Insights

Subclinical hypothyroidism (SH) impairs both right and left ventricular diastolic function, as shown by tissue Doppler echocardiography. This study reveals reduced early diastolic annular velocity and prolonged relaxation times in SH patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Diagnostic Imaging

Background:

  • Subclinical hypothyroidism (SH) is linked to cardiovascular issues like endothelial dysfunction and atherosclerosis.
  • Previous research on SH and cardiac function primarily focused on left ventricular (LV) function using tissue Doppler echocardiography (TDE).
  • The impact of SH on right ventricular (RV) function using TDE remains understudied.

Purpose of the Study:

  • To investigate the effects of SH on both RV and LV diastolic function.
  • To utilize the TDE technique for assessing ventricular function in SH patients.

Main Methods:

  • Included 36 newly diagnosed SH patients and 28 healthy controls.
  • Measured thyroid function tests (FT3, FT4, TT3, TT4, TSH) and antibodies (TPOab, TGab).
  • Performed standard echocardiography and pulsed tissue Doppler echocardiography (TDE) to assess LV and RV function.

Main Results:

  • SH patients exhibited significantly higher TSH, TPOab, and TGab levels compared to controls.
  • TDE revealed significantly lower early diastolic annular velocity (Ea) and Ea/Aa ratio in both ventricles of SH patients.
  • SH patients showed significantly prolonged isovolumetric relaxation time (IRT) for both LV and RV, indicating impaired diastolic function.

Conclusions:

  • Subclinical hypothyroidism is associated with impaired diastolic function in both the right and left ventricles.
  • TDE is a valuable tool for detecting subclinical cardiac dysfunction in SH.
  • Findings suggest a need for monitoring cardiac function in patients with SH.

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