Related Experiment Video
Updated: Aug 15, 2026

08:56
Study of Experimental Organ Donation Models for Lung Transplantation
Published on: March 15, 2024
[Organs shortage in the United States]
Masahiro Hattori1, Yuichi Iwaki
1Organs shortage in the United States.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|November 10, 2005
Summary
Japan faces a critical organ shortage, with increasing deceased donor transplants since 1997 but still insufficient to meet demand. The nation must boost its deceased donor transplant rates to address this growing public health crisis.
Area of Science:
- Medical Science
- Transplantation Medicine
- Public Health
Context:
- Deceased donor transplantation in Japan has been legal since October 1997.
- Despite legal progress, organ shortages persist, with rising waiting lists and patients seeking transplants abroad.
- The United States also experiences significant organ shortages, highlighting a global challenge.
Purpose:
- To analyze the status of deceased donor transplantation in Japan.
- To highlight the growing gap between organ demand and supply.
- To emphasize the need for Japan to increase its deceased donor transplant capacity.
Summary:
- Since 1997, Japan has performed 140 deceased donor transplants by March 2005, yet patient waiting lists continue to grow.
- Organ shortages are a critical issue in Japan and globally, exemplified by the US experience with over 86,000 patients on waiting lists in 2003.
- Initiatives like Expanded Criteria Donor (ECD) and Model for End-stage Liver Disease (MELD) scoring systems were introduced in 2002 to optimize organ allocation.
Impact:
- The findings underscore the urgent need for Japan to enhance its deceased donor transplantation programs.
- Addressing organ shortages is crucial for improving patient outcomes and reducing the need for international transplant tourism.
- Independent growth in deceased donor transplants is essential for Japan's healthcare self-sufficiency.
More Related Videos
Related Concept Videos
Tissue Transplantation
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Imbalances in Cardiac Output
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Anatomy of the Heart
The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
Pneumothorax-I
A pneumothorax is a condition where air builds up in the space between the lung and the chest wall, causing the lung to collapse. This condition arises when air enters the space between the parietal and visceral pleura, disrupting the negative pressure essential for lung inflation. This can lead to a partial or complete collapse of the lung.
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
Factors Affecting Erythropoiesis
The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...

