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Updated: Aug 15, 2026

Surgical Approach, Challenges, and Resolutions for Uterus Transplantation in Rats
Published on: April 14, 2023
[Organ transplantation and pregnancy]
Motoharu Imanaka1, Tatsuya Nakatani
1College of Nursing, Osaka City University.
Abstract:
Organ transplantation in reproductive-age women increases in frequency each year. In the presence of stable graft function and stable maintenance immunosuppressive regimens, patients are more likely to have successful outcomes. It is reasonable to advise recipients to wait at least 2 years after transplant to become pregnant. Most pregnancies do not affect graft function significantly, while they are sometimes associated with obstetric complications such as spontaneous abortions, premature deliveries, low birth weight, intrauterine growth retardation, hypertension, infection, etc. in recipients. Immunosuppressive medications can be used safely during pregnancy, and they are necessary in order to prevent maternal and fetal complications secondary to graft rejection. Successful management of the pregnant recipients requires a multidisciplinary team.
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