Relationship between preimplantation host weight and growth of the mouse adenocarcinoma EO 771

Growth curves of 26 EO 771 adenocarcinomas transplanted under identical conditions into 26 syngeneic C57bl/6 male mice of the same age but with different body weight were analyzed using the method of the recursion formula of the Gompertz function. The results of this analysis were then related to the body weight of the animals at the time of tumor implantation. Although all tumors grew according to the Gompertz mode of growth, the growth curves differed from each other. Moreover, there is a statistically significant correlation between the parameters of the individual growth curves and the corresponding animal weight at the time of tumor implantation (p less than 0.025). In animals with higher body weight the tumors grew with a higher initial growth rate and subsequently with a faster growth deceleration compared to animals with lower body weight. The physiological basis for this relationship is unknown but the question arises whether this relationship also has some meaning for human malignancies.