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Updated: Aug 14, 2026

Generation of Human Chimeric Antigen Receptor Regulatory T Cells
Published on: January 3, 2025
E3 ubiquitin ligases and their control of T cell autoreactivity
Jody L Bonnevier1, Ruan Zhang, Daniel L Mueller
1Rheumatic and Autoimmune Diseases Division, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.
Abstract:
A loss of T cell tolerance underlies the development of most autoimmune diseases. The design of therapeutic strategies to reinstitute immune tolerance, however, is hampered by uncertainty regarding the molecular mechanisms involved in the inactivation of potentially autoreactive T cells. Recently, E3 ubiquitin ligases have been shown to mediate the development of a durable state of unresponsiveness in T cells called clonal anergy. In this review, we will discuss the mechanisms used by E3 ligases to control the activation of T cells and prevent the development of autoimmunity.
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