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Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells (MSCs)
06:20

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells (MSCs)

Published on: December 24, 2015

[Immunomodulation of bone marrow mesenchymal stem cells in hematopoietic stem cell transplantation--review]

Lei Gao1, Jian-Min Wang

  • 1Department of Hematology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|November 10, 2005
PubMed

Bone marrow mesenchymal stem cells (BM-MSC) have the characteristics of self-renewal and multipotency. They secrete a variety of cytokines and provided and ideal microenvironment for the division, proliferation and differentiation of hematopoietic stem cells (HSC) through the interaction with other stromal cells. Previous studies indicated that MSC could enhance engrafment and alleviate GVHD in allo-HSC and MSC co-transplantation. This effect on transplantation immunity may associate with escaping MHC compatible HSC from antigen recognition and suppressing activation and proliferation of nonspecific lymphocytes. In this paper, the characteristics of BM-MSC influencing transplantation immunity and its mechanism were reviewed.

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