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An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
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[Folate receptor and its application in the selective receptor-mediated targeting therapy of tumor cells--review]

Xiao-Ning Gao1, Suo-Qin Tang

  • 1Department of Pediatrics, The General Hospital of PLA, 100853 Beijing, China. gaoxn@tom.com

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|November 10, 2005
PubMed

Insights

Targeting folate receptors on cancer cells offers a novel approach for drug delivery. This method shows promise for treating myeloid leukemia by directing drugs specifically to malignant cells.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Context:

  • Tumor cells express surface receptors that bind ligands, enabling targeted drug delivery via conjugates.
  • Folate receptors are overexpressed in malignant tissues, particularly myeloid leukemia cells.
  • These receptors internalize folic acid conjugates, making them ideal targets for cancer therapy.

Purpose:

  • To review the biological characteristics of folate receptors.
  • To examine folate receptor distribution in normal and cancerous tissues, with a focus on myeloid leukemia.
  • To summarize research progress in folate receptor-mediated targeting of tumor and leukemic cells.

Summary:

  • Folate receptors on tumor cells can be targeted with drug conjugates for selective delivery.
  • Their overexpression in myeloid leukemia and ability to internalize folic acid conjugates highlight their therapeutic potential.
  • This review details folate receptor biology, distribution, and its application in targeting leukemic cells.

Impact:

  • Establishes folate receptor-mediated targeting as a promising strategy for leukemic cell therapy.
  • Provides a comprehensive overview of folate receptor biology and its clinical implications.
  • Highlights the potential for developing novel, targeted therapies for myeloid leukemia.

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