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Medications associated with weight gain.

Margaret Malone1

  • 1Department of Pharmacy Practice, Albany College of Pharmacy, NY 12208-3492, USA. malonem@acp.edu

The Annals of Pharmacotherapy
|November 10, 2005
PubMed
Summary
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Some common medications can cause significant weight gain due to effects on appetite regulation. Healthcare providers should consider alternative therapies for patients prone to obesity.

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Drug Metabolism

Background:

  • Weight gain is a common side effect of many prescribed medications.
  • Understanding the mechanisms behind drug-induced weight gain is crucial for patient management.

Purpose of the Study:

  • To review literature on weight gain associated with commonly prescribed drugs.
  • To explore adjunctive therapies for managing medication-induced weight gain.

Main Methods:

  • MEDLINE literature search (1995-2005) using "weight gain/drug effects" as keywords.
  • Prioritized prospective, randomized, controlled trials; included meta-analyses and reviews.
  • Categorized studies by therapeutic area (psychiatry, neurology, diabetes).

Main Results:

Related Experiment Videos

  • Weight gain varies significantly between individuals and drug classes.
  • Drug-induced weight gain is often linked to receptor binding affecting appetite regulation.
  • Specific agents within drug classes are more likely to cause weight gain.

Conclusions:

  • Clinically significant weight gain is linked to certain commonly prescribed medications.
  • Interindividual variability in weight gain response is substantial.
  • Alternative therapies should be considered for individuals at risk of overweight and obesity.