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Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
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Analysis of KIR ligand incompatibility in human renal transplantation

T Hien Tran1, Joannis Mytilineos, Sabine Scherer

  • 1Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany.

Transplantation
|November 10, 2005
PubMed

Natural killer cells express killer immunoglobulin-like receptors (KIR) that bind to MHC class I antigens. Lack of self-MHC on the target cell can cause NK-cell mediated killing. Here, we analyzed the effect of KIR ligand incompatiblity on renal allograft survival in humans. Kidney recipient/donor pairs were separated according to their HLA-Cw alleles and HLA-Bw4 specificity which are considered epitopes for KIR. A total of 2,757 renal transplants were examined. Graft survival rates were computed according to the Kaplan-Meier method. No effect of KIR ligand matching on graft survival was observed in cadaver kidney transplants. Our results indicate that KIR ligand matching cannot be recommended as a strategy for improving renal allograft survival.

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