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Related Experiment Videos

Mitral and aortic valvular flow: quantification with MR phase mapping.

L Søndergaard1, C Thomsen, F Ståhlberg

  • 1Danish Research Centre of Magnetic Resonance, Hvidovre University Hospital, Denmark.

Journal of Magnetic Resonance Imaging : JMRI
|May 1, 1992
PubMed
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Magnetic resonance phase mapping accurately quantifies valvular blood flow, even with complex motion. This improved technique offers a reliable, noninvasive method for assessing heart valve disease.

Area of Science:

  • Cardiovascular imaging
  • Medical physics
  • Biomedical engineering

Background:

  • Magnetic resonance (MR) phase mapping is crucial for quantifying valvular blood flow.
  • Higher-order motion terms can degrade phase information, limiting accuracy.
  • Existing methods require improvement to handle complex flow dynamics.

Purpose of the Study:

  • To develop and validate an MR phase mapping sequence robust to higher-order motion.
  • To assess the accuracy of this sequence for quantifying valvular blood flow in healthy volunteers and patients.

Main Methods:

  • A modified MR sequence with reduced encoding for higher-order motion was implemented by shortening the flow-encoding gradient duration to 2.2 msec.
  • The sequence was tested on a flow phantom simulating valvular stenosis.

Related Experiment Videos

  • Quantification of mitral and aortic volume flow rates and peak velocities was performed in eight healthy volunteers and compared with indicator-dilution and Doppler echocardiography.

    • Main Results:

    • The modified sequence demonstrated robustness against higher-order motion within the clinical velocity range.
    • Statistically significant correlations were observed between MR phase mapping results and reference techniques (indicator-dilution and Doppler echocardiography).
    • Preliminary studies in patients with valvular disease suggest the technique's validity in pathologic conditions.

    Conclusions:

    • The developed MR phase mapping technique effectively overcomes limitations caused by higher-order motion.
    • This method provides accurate and noninvasive quantification of valvular blood flow.
    • MR phase mapping shows significant potential as a clinical tool for diagnosing and managing heart valve disease.