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Insulin and insulin resistance.

Gisela Wilcox1

  • 1Melbourne Pathology, Collingwood, VIC 3066, Australia. gisela.wilcox@med.monash.edu.au

The Clinical Biochemist. Reviews
|November 10, 2005
PubMed
Summary

This review explores insulin and insulin resistance, crucial for understanding obesity and diabetes epidemics. It details insulin

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Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Physiology

Background:

  • Obesity and diabetes are global epidemics.
  • Insulin resistance is increasingly recognized as a key factor.
  • Understanding insulin is vital for chronic disease management.

Purpose of the Study:

  • To provide a comprehensive overview of insulin and insulin resistance.
  • To discuss the clinical manifestations and influencing factors of insulin resistance.
  • To highlight the impact of societal changes on metabolic health.

Main Methods:

  • Literature review of insulin's history, structure, synthesis, secretion, actions, and interactions.
  • Discussion of insulin resistance, its effects on organs and tissues.
  • Analysis of physiological, environmental, and pharmacological influences.

Main Results:

  • Insulin plays a critical role in numerous physiological processes.
  • Insulin resistance is linked to various clinical syndromes and manifestations.
  • Societal shifts in lifestyle significantly impact insulin sensitivity.

Conclusions:

  • A thorough understanding of insulin and insulin resistance is essential for addressing modern chronic diseases.
  • Environmental and lifestyle factors are major contributors to insulin resistance.
  • Further research into complex biological mechanisms is needed alongside consideration of societal trends.

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