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Published on: December 18, 2016
Rates of cerebral atrophy in autopsy-confirmed progressive supranuclear palsy
Keith A Josephs1, Jennifer L Whitwell, Bradley F Boeve
1Department of Neurology, Mayo Clinic, 200 First Street NW, Rochester, MN 55905, USA. josephs.keith@mayo.edu
Objective:
To determine the rates of cerebral atrophy and ventricular expansion in six patients with autopsy confirmed progressive supranuclear palsy (PSP) and multiple antemortem volumetric head MRI scans.
Methods:
This study uses the boundary shift integral to determine rates of cerebral atrophy and ventricular expansion in six patients with pathologically confirmed PSP compared with six age- and sex-matched control subjects.
Results:
Patients with PSP had a rate of cerebral atrophy and ventricular expansion of 1.3 and 7.0% per year compared with 0.4 and 1.8% in control subjects.
Interpretation:
These rates provide a benchmark that can be used to monitor future treatment response in PSP.
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