Related Experiment Video
Updated: Aug 14, 2026

A Periprosthetic Joint Candida albicans Infection Model in Mouse
Published on: February 2, 2024
[Infectious complications after prosthesis implantation in patients with bone tumors]
Intraprosthetic infections complicate 11% of bone and joint replacement surgeries, often occurring within 3 months. Surgical intervention effectively resolves most complications, unlike anti-infective treatment alone.
Area of Science:
- Orthopedic Surgery
- Infectious Disease Research
- Biomaterials Science
Context:
- Analysis of 245 endoprosthetic bone and major joint replacement cases.
- Focus on intraprosthetic infection-related complications.
- Evaluation of risk factors and treatment outcomes.
Purpose:
- To present data on complications following endoprosthetic replacement.
- To identify factors influencing the frequency of intraprosthetic infections.
- To assess the efficacy of different treatment strategies.
Summary:
- 11% of patients experienced intraprosthetic infection-related complications.
- Complications predominantly occurred within 3 months post-surgery (64%).
- Higher infection rates were observed in revision surgeries, proximal tibia resections with knee joint replacement, and with adjuvant polychemotherapy.
- Anti-infective treatment alone was effective in only 11% of cases.
- Surgical interventions of varying extent successfully resolved complications in 75% of instances.
Impact:
- Highlights the significant complication rate of intraprosthetic infections in endoprosthetic replacements.
- Identifies high-risk patient groups and surgical scenarios.
- Emphasizes the critical role of surgical management over solely anti-infective therapy for these complications.
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06:53Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
Published on: September 9, 2020
18:40Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice
Published on: October 16, 2014
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