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Updated: Aug 2, 2026

Chronic Ovine Model of Right Ventricular Failure and Functional Tricuspid Regurgitation
Published on: March 17, 2023
Weaning from long-term mechanical ventilation
1Hospital for Special Care, New Britain, CT 06053, USA. pscalise@hfsc.org
Prolonged mechanical ventilation (PMV) affects 5% of patients. Specialized care programs can improve outcomes for these patients, addressing reversible causes of ventilation failure and potentially reducing intensive care unit (ICU) stays.
Area of Science:
- Critical Care Medicine
- Pulmonology
- Respiratory Therapy
Background:
- Prolonged mechanical ventilation (PMV) impacts up to 5% of patients requiring mechanical ventilation.
- High morbidity and healthcare costs are associated with PMV.
- Successful liberation from mechanical ventilation is a significant challenge for many patients.
Purpose of the Study:
- To review common and reversible causes of liberation failure from mechanical ventilation.
- To examine the outcomes of patients requiring PMV.
- To present evidence supporting the development of specialized units for PMV patients.
Main Methods:
- Literature review of common causes of PMV.
- Analysis of outcomes data for patients requiring PMV.
- Evidence synthesis supporting specialized care models.
Main Results:
- Identified several potentially reversible reasons for PMV.
- Demonstrated that specialized, programmatic care can lead to good outcomes.
- Highlighted the potential benefits of cohorting PMV patients in specialized units.
Conclusions:
- Specialized care and programmatic approaches are crucial for improving outcomes in PMV patients.
- Dedicated units for PMV patients may offer better results compared to prolonged ICU care.
- Addressing reversible causes of ventilation failure is key to successful liberation.
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