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Lymphocyte subpopulation number and function in infancy.

D A Stern1, M J Hicks, F D Martinez

  • 1Respiratory Sciences Center, University of Arizona Health Sciences Center, Tucson 85724.

Developmental Immunology
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

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This study establishes normal values for infant lymphocyte subpopulations and immune responses. Key findings show changes in T cells, B cells, and immune function from birth to 24 months, aiding clinical evaluations.

Area of Science:

  • Immunology
  • Pediatric Medicine
  • Developmental Biology

Background:

  • Normal values for infant lymphocyte subpopulations and immune function are not well-established.
  • Understanding immune system maturation in infancy is crucial for identifying immune deficiencies.

Purpose of the Study:

  • To establish normal reference ranges for lymphocyte subpopulations and mitogen responses in healthy infants.
  • To characterize changes in immune cell percentages and function from birth to 24 months of age.

Main Methods:

  • Analysis of lymphocyte subpopulations (CD3, CD4, CD8, CD20) and functional responses (ConA, PWM, PHA) in infant blood samples.
  • Cross-sectional (n=271) and longitudinal (n=37) study designs utilizing umbilical cord and peripheral blood samples.
  • Inclusion of healthy infants from Tucson, Arizona, with assessment for ethnic- and gender-related differences.

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Main Results:

  • Significant increases in total T cells (CD3), T-cell subsets (CD4, CD8), and B cells (CD20) from birth to later infancy.
  • Significant decreases in the CD4/CD8 ratio and responses to ConA and PWM mitogens.
  • No significant changes in PHA responsiveness or detectable ethnic/gender differences.

Conclusions:

  • Established normal values provide a critical reference for infant immune system studies and clinical diagnostics.
  • The findings highlight dynamic changes in infant immune cell populations and function during the first two years of life.
  • These data are valuable for evaluating newborns and infants with suspected acquired or congenital immune deficiencies.