Rhino-orbitocerebral entomophthoramycosis

Area of Science:

• Medical Mycology
• Infectious Diseases
• Neurology

Background:

• Conidiobolus coronatus is a known fungal pathogen.
• It commonly causes subcutaneous infections, primarily affecting the face.
• These infections are generally considered benign in immunocompetent hosts.

Observation:

• A rare case of intracranial extension of Conidiobolus coronatus infection is presented.
• The patient was immunocompetent, challenging typical disease profiles.
• The infection led to a severe rhino-orbitocerebral syndrome.

Findings:

• This is the first reported instance of C. coronatus causing intracranial disease.
• The fungus disseminated within the central nervous system.
• The rhino-orbitocerebral syndrome indicated extensive tissue involvement.

Implications:

• Highlights the potential for severe, invasive disease from C. coronatus, even in immunocompetent individuals.
• Suggests the need for heightened awareness and diagnostic vigilance for unusual presentations.
• Underscores the importance of considering fungal pathogens in complex neurological and orbital infections.