Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pulmonary cachexia, systemic inflammatory profile, and the interleukin 1beta -511 single nucleotide polymorphism.

Roelinka Broekhuizen1, Robert F Grimble, W Martin Howell

  • 1Department of Respiratory Medicine, University Hospital Maastricht, The Netherlands. r.broekhuizen@pul.unimaas.nl

The American Journal of Clinical Nutrition
|November 11, 2005
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-World Data on the Use of Follitropin Delta in a Dutch IVF Center.

Reproductive medicine and biology·2026
Same author

Array genotyping of transfusion-relevant blood cell antigens in 6946 ancestrally diverse study participants.

Blood·2025
Same author

The Timed Up and Go test predicts frailty in patients with COPD.

NPJ primary care respiratory medicine·2022
Same author

Glutathione-S-transferase P promotes glycolysis in asthma in association with oxidation of pyruvate kinase M2.

Redox biology·2021
Same author

Cognitive performance in relation to metabolic disturbances in patients with COPD.

Clinical nutrition (Edinburgh, Scotland)·2020
Same author

Daily physical activity and related risk factors in COPD.

BMC pulmonary medicine·2020

Cachexia in COPD patients doesn't significantly alter inflammatory status, but genetic factors may influence the cachexia process. Further research is needed to understand these complex interactions.

Area of Science:

  • Pulmonary Medicine
  • Genetics
  • Biochemistry

Background:

  • Cachexia is prevalent in Chronic Obstructive Pulmonary Disease (COPD) and is associated with heightened systemic inflammation.
  • Investigating the interplay between inflammation, body composition, and genetic factors in COPD cachexia is crucial for understanding disease progression.

Purpose of the Study:

  • To explore differences in systemic inflammatory profiles and inflammatory gene polymorphisms between COPD patients with and without cachexia.
  • To compare body composition and inflammatory markers between cachectic COPD patients, non-cachectic COPD patients, and healthy controls.

Main Methods:

  • Cross-sectional study of 99 COPD patients (GOLD stages II-IV) and healthy controls.
  • Body composition assessed by bioelectrical impedance analysis; cachexia defined by fat-free mass index.

Related Experiment Videos

  • Plasma cytokine levels (IL-1beta, IL-6, TNF-alpha), C-reactive protein, leptin, and urinary pseudouridine measured; gene polymorphisms analyzed.

    • Main Results:

    • Cachectic and non-cachectic COPD patients showed significant differences in fat mass, leptin, and pseudouridine levels.
    • Both COPD patient groups exhibited elevated systemic inflammation markers (CRP, sTNF-R75, IL-6) compared to healthy controls.
    • A significant difference in the distribution of the IL-1beta -511 gene polymorphism was observed among the study groups.

    Conclusions:

    • Cachexia in COPD patients does not appear to be a distinct differentiator for the degree of systemic inflammation.
    • Genetic predisposition, specifically IL-1beta gene polymorphism, may play a role in the development of cachexia in COPD.
    • Further investigation into genetic factors influencing COPD cachexia is warranted.