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Related Experiment Videos

Brain metastases.

Andrew D Norden1, Patrick Y Wen, Santosh Kesari

  • 1Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.

Current Opinion in Neurology
|November 11, 2005
PubMed
Summary
This summary is machine-generated.

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New treatments for brain metastases offer improved outcomes for cancer patients. Stereotactic radiosurgery is a promising alternative to surgery, with ongoing research into chemotherapy and targeted agents.

Area of Science:

  • Neuro-oncology
  • Radiation Oncology
  • Medical Oncology

Background:

  • Brain metastases affect 10-30% of cancer patients, often with a poor prognosis.
  • Surgical resection is recommended for single, surgically accessible metastases in patients with good prognostic factors.
  • Management of multiple, unresectable, or poor-prognosis brain metastases remains controversial.

Purpose of the Study:

  • To review recent data on the management of brain metastases.
  • To discuss current and emerging treatment options for patients with brain metastases.

Main Methods:

  • Review of recently published data on brain metastases treatment.
  • Analysis of outcomes associated with radiation therapy, surgery, and emerging therapies.

Related Experiment Videos

Main Results:

  • Radiation therapy reduces local recurrence after surgery but not survival.
  • Stereotactic radiosurgery is an emerging alternative to surgery with similar outcomes and less morbidity.
  • Investigational therapies include interstitial brachytherapy, novel chemotherapeutics, and targeted molecular agents.

Conclusions:

  • Patients with brain metastases have increasing treatment options for improved outcomes.
  • Randomized trials are needed to compare radiosurgery and surgery.
  • Future research should evaluate quality of life, neurocognitive function, and the role of novel systemic agents.