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Relationship between body size and prostate cancer in a sibling based case-control study
Xin Liu1, Benjamin A Rybicki, Graham Casey
1Department of Epidemiology and Biostatistics, University of California-San Francisco, 500 Parnassus Avenue, San Francisco, CA 94143-0560, USA.
The Journal of Urology
|November 11, 2005
Summary
Higher lean body mass (LBM) is linked to a lower risk of prostate cancer (PCa), particularly for aggressive forms. This finding suggests LBM plays a role in prostate cancer development and progression.
Area of Science:
- Oncology
- Epidemiology
- Human Physiology
Background:
- Body size is a potential factor influencing prostate cancer (PCa) risk.
- Previous research on body size and PCa risk has yielded inconsistent findings, with some studies reporting positive, inverse, or null associations.
Purpose of the Study:
- To investigate the association between body size metrics (weight, height, body mass index, and lean body mass [LBM]) and the risk and aggressiveness of prostate cancer (PCa).
- To clarify the relationship between body composition and PCa in a sibling-based case-control study.
Main Methods:
- A case-control study involving 439 PCa cases and 479 unaffected brothers as controls.
- Conditional logistic regression with robust variance estimation was employed to analyze the associations between body size parameters and PCa risk.
Main Results:
- Increased lean body mass (LBM) showed an inverse association with prostate cancer (PCa) risk, especially in men with more aggressive disease or later onset.
- Men with higher LBM had a significantly reduced odds ratio (OR) for PCa.
- Weight also demonstrated an inverse relationship with PCa, while height and body mass index showed no significant associations.
Conclusions:
- Lean body mass (LBM) appears to be a significant factor influencing prostate cancer (PCa) risk and potentially its aggressiveness.
- The findings suggest that LBM may play a protective role against PCa development or progression.