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Does the less aggressive multimodal approach of treating bladder-prostate rhabdomyosarcoma preserve bladder function?
Roberto Soler1, Antonio Macedo, Homero Bruschini
1Department of Urology, Federal University of São Paulo, São Paulo, Brazil.
The Journal of Urology
|November 11, 2005
Summary
Multimodal therapy for bladder-prostate rhabdomyosarcoma preserved the bladder in most children. Bladder function was mostly maintained, with only one patient requiring urinary diversion.
Area of Science:
- Pediatric Oncology
- Urology
- Radiation Oncology
Background:
- Bladder-prostate rhabdomyosarcoma treatment has advanced to multimodal approaches.
- Organ-sparing surgery with bladder preservation is a key component of modern therapy.
Purpose of the Study:
- To investigate bladder function in pediatric patients with bladder-prostate rhabdomyosarcoma.
- To assess outcomes in children who retained their original bladder after multimodal treatment.
Main Methods:
- Evaluation of 8 children treated between 1999-2003.
- Inclusion criteria: retained bladder for at least 6 months post-treatment.
- Methods: history, physical examination, and urodynamic studies.
Main Results:
- 37.5% of patients had asymptomatic, normal urodynamic studies.
- 4 patients experienced urological complaints with findings like reduced bladder capacity and overactivity.
- Only 1 patient ultimately required cystectomy and urinary diversion.
Conclusions:
- Multimodal therapy successfully preserved the native bladder in 7 of 8 patients.
- Most patients experienced minor, tolerable bladder function alterations.
- Long-term follow-up is essential to fully assess radiotherapy effects.