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Related Experiment Videos

Growth hormone and tumour recurrence.

A L Ogilvy-Stuart1, W D Ryder, H R Gattamaneni

  • 1Department of Endocrinology, Christie Hospital and Holt Radium Institute, Manchester.

BMJ (Clinical Research Ed.)
|June 20, 1992
PubMed
Summary

Growth hormone treatment for radiation-induced deficiency in children with brain tumors did not increase tumor recurrence risk. Continued surveillance is recommended, and abnormal CT scans do not preclude growth hormone therapy.

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Area of Science:

  • Pediatric Oncology
  • Endocrinology
  • Radiology

Background:

  • Radiation therapy for childhood brain tumors can cause growth hormone deficiency.
  • Growth hormone (GH) replacement therapy is used to treat this deficiency.
  • Concerns exist regarding the potential impact of GH on tumor recurrence.

Purpose of the Study:

  • To evaluate the risk of tumor recurrence in children treated with growth hormone for radiation-induced growth hormone deficiency.
  • To assess the safety of growth hormone therapy in pediatric cancer survivors.

Main Methods:

  • Retrospective comparison of tumor recurrence rates in children with brain tumors who received GH versus those who did not.
  • Review of computed tomograms (CT) before and during GH treatment.

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  • Analysis included patients with brain tumors and acute lymphoblastic leukemia.

    • Main Results:

    • In children with brain tumors, 11% of those on GH experienced recurrence versus 26% of those not on GH.
    • The relative risk of recurrence with GH was 0.82 (95% CI 0.28 to 2.37), indicating no significant increase.
    • Abnormal CT findings at baseline did not preclude successful GH treatment in relapsed patients.

    Conclusions:

    • Growth hormone therapy did not appear to increase tumor recurrence risk in this cohort.
    • Continued patient surveillance remains crucial.
    • Abnormal CT findings should not be considered an absolute contraindication for GH treatment.