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Adriamycin resistance is characterized by ultrastructural changes in human leukaemic K562 cells in vitro
H Bobichon1, M G Okiemi, C Broglio
1Laboratoire de Biologie et GIBSA, UFR Pharmacie, Reims, France.
Biology of the Cell
|January 1, 1992
Abstract:
Ultrastructural changes associated with adriamycin (ADM) resistance have been investigated in the human K562 leukaemic cell line: sensitive K562 cells, a resistant subline cultured in the continuous presence of ADM and resistant cells without ADM Transmission electron microscopy (TEM) study revealed that K562-resistant cells displayed ultrastructural modifications of the cell surface, chromatin and nucleolus conformation. Alterations were not directly related to the presence of adriamycin as deprivated cells exhibited modificated characters through a slow progressive recovery phenomenon.