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A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure
07:13

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure

Published on: April 30, 2020

[Variants of heart remodeling in essential hypertension: prevalence and determinants]

A O Konradi, O G Rudomanov, D V Zakharov

    Terapevticheskii Arkhiv
    |November 12, 2005
    PubMed

    Insights

    Hypertension impacts heart structure, with obesity, age, and gender influencing left ventricular remodeling. These factors, alongside blood pressure, dictate the severity and type of cardiac changes in essential hypertension.

    Area of Science:

    • Cardiology
    • Hypertension Research
    • Cardiac Imaging

    Context:

    • Essential hypertension (EH) is a prevalent condition.
    • Myocardial remodeling (MR) and left ventricular remodeling (LVR) are key indicators of cardiovascular risk in hypertensive patients.
    • Understanding factors influencing MR is crucial for risk stratification and management.

    Purpose:

    • To investigate myocardial remodeling in hypertensive patients with varying body mass.
    • To analyze the relationship between clinical/hemodynamic parameters and MR features.
    • To determine the type of left ventricular remodeling (LVR) in relation to patient demographics and disease characteristics.

    Summary:

    • Echocardiography was used to assess structural-functional myocardial conditions in 734 untreated hypertensive patients.
    • Eccentric left ventricular hypertrophy (LVH) was common in stage I EH.
    • Concentric LVH prevalence increased with age, disease severity, and was more frequent in males; obesity, particularly android type, significantly exacerbated LVH in both genders, especially females.

    Impact:

    • Findings highlight that age, gender, EH duration, and obesity type/degree significantly influence cardiac structural alterations and LVR variants beyond arterial pressure.
    • Provides insights into personalized risk assessment for hypertensive patients.
    • Informs targeted therapeutic strategies for managing myocardial remodeling in hypertension.
    Abstract

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