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Discovery of Metastatic Regulators using a Rapid and Quantitative Intravital Chick Chorioallantoic Membrane Model
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Published on: February 3, 2021

[Pemphigoid gestationis--first sign of metastatic choriocarcinoma]

Kathrin Sinemus1, Detlef Zillikens, Percy Lehmann

  • 1Hautklinik Wuppertal, Klinik für Dermatologie, Allergologie und Umweltmedizin, Klinikum der Universität Witten-Herdecke, Helios Klinikum Wuppertal GmbH. Dr.KathrinSinemus@web.de

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|November 12, 2005
PubMed

A 29-year-old woman developed pruritic urticarial plaques and vesicles 3 months after delivery of a healthy daughter. Two months later pemphigoid gestationis (PG) was diagnosed based on histopathological and immunopathological findings. At the same time elevated serum levels for beta-HCG and a large mass in the liver were noted. A liver biopsy confirmed the diagnosis of metastatic choriocarcinoma, which was responsible for the PG metastasis. Upon initiation of chemotherapy, complete healing of the PG was observed within 4 weeks and autoantibodies to BP180NC16A could no longer be identified. In parallel, both a decrease of beta-HCG levels and tumor size was observed.

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