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Updated: Aug 14, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
[The "red melanoma"--a rare form of amelanotic malignant melanoma]
Brigitte Coras1, Silvia Hohenleutner, Kerstin Raff
1Klinik und Poliklinik für Dermatologie der Universität Regensburg.
Abstract:
The two major variants of amelanotic malignant melanoma are the verrucous and the polypoid forms. A further--albeit rare--red eczematous variety has also been described. We report two female patients with reddish, non-pigmented, scaly lesions on the upper arm and the shoulder that had developed 2 to 3 years previously. One biopsy showed the diagnosis of a melanoma growing in situ while the second revealed a highly atypical melanocytic tumour. However, the histopathological examination of the entire tumour showed a superficial spreading amelanotic malignant melanoma. Therefore, in non-healing erythematous lesions, even without pigmentation or ulceration, the rare differential diagnosis of amelanotic malignant melanoma should be taken in consideration and a biopsy should be performed prior to therapy without histological control.
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