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Related Experiment Videos

Multifocal angiostatic therapy: an update.

Mark F McCarty1, Keith I Block

  • 1Block Center for Integrative Cancer Care, Evanston, Illinois 60201, USA. mccarty@pantox.com

Integrative Cancer Therapies
|November 12, 2005
PubMed
Summary
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Multifocal angiostatic therapy (MAT) combines nutraceuticals and lifestyle changes to inhibit cancer angiogenesis. New evidence supports adding diindolylmethane and silymarin to regimens targeting key molecular pathways for improved cancer treatment.

Area of Science:

  • Oncology
  • Nutraceuticals
  • Molecular Biology

Background:

  • Cancer angiogenesis is crucial for tumor growth and metastasis.
  • Multifocal angiostatic therapy (MAT) targets multiple pathways regulating angiogenesis.
  • Existing MAT prototypes include nutraceuticals, diet, exercise, and tetrathiomolybdate (TM).

Purpose of the Study:

  • To review recent evidence on MAT constituents and identify potential additions.
  • To clarify the mechanisms of action for MAT components.
  • To explore dual-purpose molecular targets for combined anti-angiogenic and anti-cancer effects.

Main Methods:

  • Literature review of recent scientific evidence.
  • Analysis of in vitro and in vivo studies on angiostatic agents.

Related Experiment Videos

  • Identification of molecular targets and potential therapeutic agents.

    • Main Results:

    • Diindolylmethane and silymarin show promising angiostatic effects in preclinical models.
    • Green tea polyphenols likely inhibit VEGFR-2 kinase activity.
    • Glycine's angiostatic effect may involve endothelial cell hyperpolarization.
    • Tetrathiomolybdate (TM) downregulates NF-kappaB activation in cancer cells.
    • NF-kappaB, cox-2, c-Src, Stat3, and hsp90 are identified as dual-purpose targets.

    Conclusions:

    • MAT is a promising strategy for cancer treatment by targeting angiogenesis.
    • Diindolylmethane and silymarin warrant inclusion in advanced MAT regimens.
    • Further research, including preclinical xenograft models, is needed to assess MAT component complementarity.