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Updated: Aug 14, 2026
Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
Published on: June 26, 2020
Neurogenesis in rats after focal cerebral ischemia is enhanced by indomethacin
Benjamin D Hoehn1, Theo D Palmer, Gary K Steinberg
1Department of Neurosurgery, Stanford University, Stanford, CA, USA.
Background And Purpose:
Newborn cells may participate in repair following ischemic brain injury, but their survival and function may be influenced by inflammation.
Methods:
We investigated the effects of indomethacin, a nonsteroidal antiinflammatory drug, on the fate of newborn cells following transient focal ischemia.
Results:
Bromodeoxyuridine (BrdU)-labeled cells, including migrating neuroblasts, were observed in the neighboring striatum and overlying cortex 1 day poststroke. The density of BrdU+ cells labeled with doublecortin, nestin, glial fibrillary acidic protein, or NG2 was increased at 14 and 28 days. Indomethacin increased BrdU+ cells of all lineages and reduced microglial/monocyte activation.
Conclusions:
Indomethacin enhanced the accumulation of newborn cells following stroke.
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