Related Experiment Video

Updated: Aug 14, 2026

Functional Transcranial Doppler Ultrasound for Monitoring Cerebral Blood Flow
09:41

Functional Transcranial Doppler Ultrasound for Monitoring Cerebral Blood Flow

Published on: March 15, 2021

Transcranial Doppler in adult patients with sickle cell disease

Gisele Sampaio Silva1, Perla Vicari, Maria Stella Figueiredo

  • 1Federal University of São Paulo, São Paulo, Brazil. giselesampaio@hotmail.com

Cerebrovascular Diseases (Basel, Switzerland)
|November 12, 2005
PubMed

Insights

Transcranial Doppler (TCD) velocities in sickle cell disease (SCD) adults differ from children and controls. New age-specific criteria may help detect stroke risk in adults with SCD.

Area of Science:

  • Neurology
  • Hematology
  • Vascular Medicine

Background:

  • Transcranial Doppler (TCD) is crucial for stroke risk assessment in pediatric sickle cell disease (SCD).
  • The utility and velocity patterns of TCD in adults with SCD remain largely uncharacterized.
  • Stroke risk stratification in adults with SCD requires further investigation.

Purpose of the Study:

  • To investigate the pattern of TCD velocities in adults with SCD.
  • To compare TCD velocities between adults with SCD and healthy controls.
  • To explore the relationship between TCD velocities and hematocrit levels in SCD adults.

Main Methods:

  • A comparative study involving 56 adults with SCD and 56 healthy controls.
  • Measurement and analysis of TCD velocities in both participant groups.
  • Correlation analysis between TCD velocities and hematocrit levels.

Main Results:

  • TCD velocities were lower in SCD adults compared to pediatric SCD patients.
  • TCD velocities were higher in SCD adults than in healthy controls.
  • A negative correlation between TCD velocities and hematocrit was observed in both SCD adults and controls.

Conclusions:

  • The TCD velocity pattern in adults with SCD is distinct from that in children.
  • Age-specific TCD criteria are necessary for accurate stroke risk detection in adults with SCD.
  • Further research into TCD applications for adult SCD patients is warranted.
Abstract

More Related Videos

Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound10:41

Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound

Published on: June 3, 2021

Related Concept Videos

Assessing Blood pressure using a doppler ultrasound01:19

Assessing Blood pressure using a doppler ultrasound

To obtain accurate blood pressure measurements in clinical settings, especially when traditional methods are insufficient, healthcare professionals utilize the Doppler ultrasound technique. This method uses high-frequency sound waves to detect blood flow within the arteries, which is crucial for patients with conditions that complicate circulatory system assessment.
Pre-Procedural Guidelines for Doppler Ultrasound Blood Pressure Assessment:
Preparation of Equipment:
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Equipments Used To Measure Blood Pressure01:30

Equipments Used To Measure Blood Pressure

Direct Method
This invasive approach involves cannulating a peripheral artery. During each cardiac contraction, pressure generates mechanical motion within the catheter, transmitted through rigid, fluid-filled tubing to a transducer. This transducer converts mechanical motion into electrical signals displayed as waveforms on a monitor. An automatic flushing system prevents blood backflow. Due to the potential risk of unexpected arterial blood loss, this method is primarily used in intensive...