Related Experiment Video

Updated: Aug 14, 2026

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

[Exploration of novel molecular targets for cancer therapy based on genomic aberrations]

Issei Imoto1, Johji Inazawa

  • 1Dept. of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|November 12, 2005
PubMed

Insights

Cancer develops from genetic instability and selection. Researchers used array-based comparative genomic hybridization (CGH-array) to identify new cancer gene targets, finding amplification target oncogenes and tumor suppressor genes.

Area of Science:

  • Genomics
  • Cancer Biology
  • Molecular Oncology

Context:

  • Tumorigenesis involves genetic instability and clonal selection, leading to advantageous genetic aberrations.
  • Various instabilities, including point mutations, chromosomal rearrangements, and epigenetic changes, contribute to cancer development.
  • Genomic copy-number aberrations serve as key landmarks for identifying novel cancer therapeutic targets.

Purpose:

  • To identify novel molecular targets for cancer therapy by focusing on genomic copy-number aberrations.
  • To leverage advances in array-based comparative genomic hybridization (CGH-array) for detailed chromosomal examination.
  • To screen cancer-related genes and potential molecular targets using an in-house CGH-array system.

Summary:

  • The study utilized an in-house CGH-array to analyze genomic copy-number aberrations in tumors.
  • This approach identified several amplification target oncogenes and tumor suppressor genes.
  • The findings highlight the utility of genomic arrays, including CGH-array, for rapid discovery of therapeutic targets.

Impact:

  • Accelerates the identification of useful molecular targets for cancer therapy.
  • Provides a detailed method for exploring genomic and epigenomic abnormalities in cancer.
  • Contributes to the development of more effective cancer treatments by pinpointing critical genes.

More Related Videos

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells09:37

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...