Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stress response in mesoangioblast stem cells.

F Geraci1, G Turturici, D Galli

  • 1Dipartimento di Biologia Cellulare e dello Sviluppo, Università di Palermo, Palermo, Italy.

Cell Death and Differentiation
|November 12, 2005
PubMed
Summary

Mesoangioblast stem cells constitutively produce heat shock protein 70 (HSP70). They can further increase HSP70 synthesis in response to heat and cadmium, indicating a robust stress response mechanism.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First Measurement of Time-Dependent CP Violation in the Flavor-Changing Neutral-Current Decay B^{0}→K_{S}^{0}μ^{+}μ^{-}.

Physical review letters·2026
Same author

Measurement of the Top-Quark Production Cross Section and Charge Asymmetry at LHCb.

Physical review letters·2026
Same author

Searches for B^{0}→K^{+}π^{-}τ^{+}τ^{-} and B_{s}^{0}→K^{+}K^{-}τ^{+}τ^{-} Decays.

Physical review letters·2026
Same author

First Evidence of the B_{s}^{0}→K^{-}π^{+}γ Decay.

Physical review letters·2026
Same author

Precision Measurement of CP Violation and Branching Fractions in B^{±}→K_{S}^{0}h^{±} (h=π, K) Decays and Search for the Rare Decay B_{c}^{±}→K_{S}^{0}K^{±}.

Physical review letters·2026
Same author

First Observation of the B[over ¯]_{s}^{0}→Λ_{c}^{+}Λ[over ¯]_{c}^{-} Decay and Evidence for the B[over ¯]^{0}→Λ_{c}^{+}Λ[over ¯]_{c}^{-} Decay.

Physical review letters·2026

Area of Science:

  • Cell Biology
  • Stem Cell Biology
  • Molecular Biology

Background:

  • Stem cells are recruited to damaged tissues, facing potential stress from inflammatory environments.
  • Understanding stem cell stress resilience is crucial for regenerative medicine.

Purpose of the Study:

  • To investigate the stress response of mesoangioblast stem cells.
  • To analyze heat shock protein 70 (HSP70) synthesis as an indicator of cellular stress.

Main Methods:

  • Exposure of A6 mesoangioblast stem cells to various stressors: heat, heavy metals (cadmium, copper), and osmotic stress.
  • Analysis of heat shock protein 70 (HSP70) synthesis and heat shock transcription factor (HSF) activation.

Main Results:

  • A6 mesoangioblasts constitutively synthesize HSP70 independently of heat shock transcription factor (HSF).

Related Experiment Videos

  • Heat shock and cadmium treatment induce increased HSP70 synthesis in an HSF1-dependent manner.
  • Copper exposure or hypertonic conditions did not induce HSP70 synthesis or HSF1 activation.

    • Conclusions:

    • Mesoangioblasts constitutively express HSP70, suggesting a pre-emptive stress defense.
    • These stem cells retain the capacity to modulate HSP70 production in response to specific environmental challenges.