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Updated: Aug 14, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Sequential evaluation of clinical and laboratory changes amongst children suffering from lupus nephritis during

Shih-Jung Chiu1, Liang-Shiou Ou, Tien-Lung Tsai

  • 1Department of Pediatrics, Chang Gung Children's Hospital and Chang Gung University, Taoyuan, Taiwan.

Clinical Rheumatology
|November 12, 2005
PubMed

Insights

Intermittent intravenous cyclophosphamide (IC) therapy significantly improved kidney function and serological markers in children with lupus nephritis over 24 months. This treatment offers a safe and effective option for pediatric systemic lupus erythematosus (SLE) patients.

Area of Science:

  • Pediatric Nephrology
  • Rheumatology
  • Immunology

Background:

  • Lupus nephritis is a severe complication of childhood systemic lupus erythematosus (SLE).
  • Effective and safe treatment options for pediatric lupus nephritis are crucial.

Purpose of the Study:

  • To evaluate the efficacy and safety of a 24-month intermittent intravenous cyclophosphamide (IC) therapy in children with lupus nephritis.
  • To assess the impact of IC therapy on serological parameters and renal function.

Main Methods:

  • Prospective evaluation of eight children with severe lupus nephritis.
  • Treatment with IC monthly for 6 months, then quarterly for 24 months.
  • Statistical analysis of sequential serological parameters and renal function tests.

Main Results:

  • Significant improvements in urine creatinine clearance, 24-h urine protein excretion, and serum creatinine levels.
  • Significant improvements in C3, C4, albumin, triglyceride levels, hemoglobin, and erythrocyte sedimentation rate.
  • Transient decrease in lymphocyte count; one case of myelotoxicity without infection; rapid steroid tapering possible.

Conclusions:

  • A 24-month course of intermittent intravenous cyclophosphamide (IC) is effective for treating lupus nephritis in children.
  • IC therapy demonstrates significant improvements in renal function and serological markers.
  • The treatment is generally safe, allowing for steroid dose reduction and resolution of hyperlipidemia.

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