[Prognostic relevance of histopathologic subtyping of mixed-cell Hodgkin's disease]

Mixed cellular (MC) type of Hodgkin disease was studied in a group of 92 bioptic cases diagnosed before the start of treatment. A precise histological analysis showed one subtype with lower malignancy (MC 1) and a second one with higher malignancy (MC 2). Subtype MC 1 comprised 61 cases (66 per cent), subtype MC 2 31 cases (34 per cent). Histomorphological subtyping was brought into correlation with clinical data of survival available in 65 cases (44 cases of subtype MC 1,21 cases of subtype MC 2). Different survival in both subtypes had statistical significance and prognostic relevance. Suggested subtyping is simple, based on common histological slides, without need of special additional investigation.