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Related Experiment Videos

Bone ingrowth in retrieved Bryan Cervical Disc prostheses.

Wade K Jensen1, Paul A Anderson, Louis Nel

  • 1Department of Orthopedic Surgery and Rehabilitation, University of Wisconsin, Madison, WI 53792, USA.

Spine
|November 15, 2005
PubMed
Summary

This study assessed bone ingrowth in Bryan Cervical Discs in chimpanzees and humans. Results showed significant bone ingrowth, indicating successful osseointegration for cervical disc prostheses.

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Area of Science:

  • Orthopedic surgery
  • Biomaterials science
  • Spinal fusion research

Background:

  • Bone ingrowth in cervical disc prostheses is not well-documented.
  • Assessing osseointegration is crucial for implant success.

Purpose of the Study:

  • To evaluate bone ingrowth into retrieved Bryan Cervical Discs.
  • To document the extent of osseointegration in primate and human explants.

Main Methods:

  • Explant analysis of retrieved Bryan Cervical Discs from two chimpanzees and two human patients.
  • Histologic and fluorochrome-labeled section analysis to assess bone ingrowth.
  • Radiographic evaluation for implant fixation.

Main Results:

  • Chimpanzee explants showed 10-50% bone apposition through porous coatings.

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  • Human explants demonstrated a mean bone ingrowth of 30.1% across all surfaces.
  • Histology confirmed new bone formation, not just impaction.

    • Conclusions:

    • Bryan Cervical Discs exhibited adequate bone apposition and significant ingrowth in both primate and human subjects.
    • Osseointegration rates are comparable to hip and knee arthroplasty.
    • Implants achieved stable fixation, as evidenced by radiographic and explant analysis.