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Sesquiterpenoids from Vernonia cinerea
Xin Chen1, Zha-Jun Zhan, Jian-Min Yue
1State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, P.R. China 201203.
Natural Product Research
|November 16, 2005
Summary
A new compound, vernocinolide A, and ten known sesquiterpenoids were isolated from Vernoniacinerea. Nine known compounds were identified in this plant for the first time, expanding knowledge of its chemical constituents.
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Organic Chemistry
Context:
- Vernoniacinerea is a plant species known for its diverse chemical profile.
- Sesquiterpenoids are a class of natural products with significant biological activities.
- Previous phytochemical investigations of Vernoniacinerea have identified various secondary metabolites.
Purpose:
- To isolate and characterize novel and known sesquiterpenoids from Vernoniacinerea.
- To elucidate the chemical structure of newly discovered compounds using spectroscopic techniques.
- To contribute to the understanding of the chemotaxonomy and chemical diversity of the Vernonia genus.
Summary:
- A new sesquiterpenoid, vernocinolide A, was isolated and its structure determined via spectroscopic analysis.
- Ten known sesquiterpenoids were also identified from the ethyl acetate soluble fraction.
- Nine of these known sesquiterpenoids represent the first reported isolation from this plant species.
Impact:
- The discovery of vernocinolide A expands the repertoire of known sesquiterpenoids.
- This study enriches the phytochemical database of Vernoniacinerea, providing valuable reference compounds.
- The findings may facilitate further research into the biological activities and potential applications of these isolated compounds.