Related Experiment Video
Updated: Aug 14, 2026
Modified Mouse Model of Repetitive Mild Traumatic Brain Injury Incorporating Thinned-Skull Window and Fluid Percussion
Published on: April 19, 2024
Changes in bone metabolism in a rat model of traumatic brain injury
Jong In Lee1, Jong Hyun Kim, Hye Won Kim
1Department of Rehabilitation Medicine, College of Medicine, The Catholic University of Korea, Seocho-Gu, Seoul, Korea.
Primary Objective:
To evaluate the process of bone metabolism after traumatic brain injury.
Research Design:
Randomized controlled trial.
Methods And Procedures:
Rats were randomly assigned to either the brain injury group or to the sham-operation group using a fluid percussion device. The BMDs of lumbar vertebrae and proximal femur and bone turnover markers, osteocalcin and carboxy-terminal telopeptide, were measured at three points: the day before surgery and 1 and 3 weeks post-operatively. The biomechanics (maximum load of tibia and femoral neck) were measured 3 weeks post-operatively.
Main Outcomes And Results:
There was significant change in the BMDs of lumbar vertebrae 1 week post-operatively and of both distal femurs 3 weeks post-operatively (p < 0.05). A significant change in the maximum load of femoral neck was also observed 3 weeks post-operatively between the brain injury and the sham-operation groups (p = 0.044).
Conclusions:
This finding suggests that brain injury could induce osteoporosis by immobilization.
