Related Experiment Video
Updated: Aug 14, 2026

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
Published on: April 2, 2012
Postinfectious myeloradiculoneuropathy with cranial nerve involvements associated with human herpesvirus 7 infection
Takateru Mihara1, Tatsuro Mutoh, Tetsusi Yoshikawa
1Department of Neurology, Fujita Health University School of Medicine, Aichi, Japan.
Background:
Infection with human herpesvirus 7 (HHV-7) generally results in a febrile illness with accompanying exanthema subitum.
Objectives:
To ascertain and describe the role of HHV-7 in a case of acute myeloradiculoneuropathy.
Patient:
A previously healthy young man with complaints of motor weakness, dysphasia, and nasal voice.
Methods:
Serological examinations were performed with the patient's serum. We also examined virus genome DNA in cerebrospinal fluid by regular and real-time polymerase chain reaction. Moreover, we checked the antiganglioside antibody level in the patient's serum samples by the immunoblot analysis.
Results:
Serological studies revealed significant change in titers of antibodies against cytomegalovirus, Epstein-Barr virus, and HHV-7, but only HHV-7 genome was detected in the cerebrospinal fluid, with its disappearance after therapy. No antiganglioside antibody was detected in the patient's serum.
Conclusion:
The unique clinical picture of the present patient might be closely related to the reactivation of HHV-7 in the nervous system.
Related Concept Videos
Encephalitis ll: Pathophysiology
Poliomyelitis
Chickenpox
Encephalitis l: Introduction
Herpes
Cytomegalovirus Disease

