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Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
Published on: March 23, 2011
NMDA receptor-independent long-term depression correlates with successful aging in rats
Hey-Kyoung Lee1, Sun Seek Min, Michela Gallagher
1Department of Neuroscience, The Mind/Brain Institute, Baltimore, Maryland 21218, USA.
Nature Neuroscience
|November 16, 2005
Abstract:
Some individuals maintain high cognitive functioning at older ages. Here we show that mechanisms for long-term depression differ in aged rodents that maintain cognitive performance compared to young adults. Our results imply that cognitive abilities may be sustained in aged individuals by a switch in synaptic plasticity mechanisms.
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