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Updated: Aug 14, 2026

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
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Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Published on: February 25, 2021

Lipid phase control of DNA delivery

Rumiana Koynova1, Li Wang, Yury Tarahovsky

  • 1Biochemistry, Molecular & Cell Biology, Northwestern University, Evanston, Illinois 60208, USA. r-tenchova@northwestern.edu

Bioconjugate Chemistry
|November 17, 2005
PubMed
Summary

Cationic lipid formulations effective for DNA delivery form specific nanoscale complexes (lipoplexes) that exhibit high negative interfacial curvature upon interaction with cell membrane lipids. This structural property is key to optimizing gene transfection efficiency.

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