Wheezing during the first year of life in infants from low-income population: a descriptive study

J Mallol1, R Andrade, F Auger

  • 1Department of Pediatric Respiratory Medicine, Faculty of Medical Sciences, University of Santiago de Chile (USACH), Hospital CRS El Pino, Santiago, Chile. jmallol@usach.cl

Insights

Recurrent wheezing (RW) is common in infants in developing regions, with over 80% experiencing episodes and 43% having RW. Early wheezing increases the risk of RW and pneumonia (PN).

Area of Science:

  • Pediatrics
  • Global Health
  • Epidemiology

Background:

  • Recurrent wheezing (RW) significantly contributes to infant morbidity and mortality in developing regions.
  • The actual incidence of RW in these areas remains largely unknown.
  • Understanding RW prevalence is crucial for public health initiatives.

Purpose of the Study:

  • To determine the incidence and characteristics of wheezing during the first year of life in a low-income urban population in Santiago, Chile.
  • To identify risk factors for RW and its association with pneumonia (PN).

Main Methods:

  • A birth cohort of 188 infants was followed monthly for one year.
  • Data collected included the occurrence of wheezing episodes and diagnosis of pneumonia (PN).
  • Statistical analysis identified risk factors for RW and PN.

Main Results:

  • 80.3% of infants experienced at least one wheezing episode in the first year.
  • 43.1% had recurrent wheezing (RW), defined as 3 or more episodes.
  • 44.1% had their first wheezing episode within the first three months of life; 13.3% developed pneumonia (PN).

Conclusions:

  • A high prevalence of RW was observed in this low-income infant population.
  • Early onset of wheezing (within the first three months) was a primary risk factor for developing RW.
  • RW was significantly associated with pneumonia (PN), especially within the first six months of life.
Abstract

Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Assessment of Respiration01:23

Assessment of Respiration

The respiratory system's basic structures and primary functions lay the foundation for nurses' comprehensive respiratory assessments. This assessment includes subjective and objective data to gauge the patient's respiratory health.
Subjective Assessment: Nurses interview the patient to gather information directly during the subjective assessment. It includes questions about the individual's medical history, medications, and symptoms, focusing on past respiratory conditions like asthma or COPD,...
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma