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Published on: May 10, 2024
Wheezing during the first year of life in infants from low-income population: a descriptive study
1Department of Pediatric Respiratory Medicine, Faculty of Medical Sciences, University of Santiago de Chile (USACH), Hospital CRS El Pino, Santiago, Chile. jmallol@usach.cl
Insights
Recurrent wheezing (RW) is common in infants in developing regions, with over 80% experiencing episodes and 43% having RW. Early wheezing increases the risk of RW and pneumonia (PN).
Area of Science:
- Pediatrics
- Global Health
- Epidemiology
Background:
- Recurrent wheezing (RW) significantly contributes to infant morbidity and mortality in developing regions.
- The actual incidence of RW in these areas remains largely unknown.
- Understanding RW prevalence is crucial for public health initiatives.
Purpose of the Study:
- To determine the incidence and characteristics of wheezing during the first year of life in a low-income urban population in Santiago, Chile.
- To identify risk factors for RW and its association with pneumonia (PN).
Main Methods:
- A birth cohort of 188 infants was followed monthly for one year.
- Data collected included the occurrence of wheezing episodes and diagnosis of pneumonia (PN).
- Statistical analysis identified risk factors for RW and PN.
Main Results:
- 80.3% of infants experienced at least one wheezing episode in the first year.
- 43.1% had recurrent wheezing (RW), defined as 3 or more episodes.
- 44.1% had their first wheezing episode within the first three months of life; 13.3% developed pneumonia (PN).
Conclusions:
- A high prevalence of RW was observed in this low-income infant population.
- Early onset of wheezing (within the first three months) was a primary risk factor for developing RW.
- RW was significantly associated with pneumonia (PN), especially within the first six months of life.
Background:
Recurrent wheezing (RW) plays an important role in the morbidity and mortality of children during the first year of life in developing regions and its actual incidence in those areas is virtually unknown.
Methods And Results:
This study describes the occurrence of wheezing during the first year of life in a birth cohort of 188 infants followed monthly and living in a poor urban area in Santiago de Chile. This study showed that 80.3 % of the infants in the cohort had one or more wheezing episode during the first year of life, 43.1 % had RW (3 or more wheezing episodes), 44.1 % had their first wheezing within the first three months of life and 13.3 % had pneumonia (PN). Having one or more episode of wheezing in the first three months of life was the main risk factor for suffering from RW during the first year and RW was a significant risk factor for having PN.
Conclusions:
This study found a high prevalence of RW in infants from a low-income population during the first year of life with the disease starting very early in their lives, progressing with more frequent episodes and being significantly associated to PN, particularly in the first 6 months of life.
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