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Nimesulide-induced fixed drug eruption.

D Malheiro¹, S Cadinha, J Rodrigues

¹Allergy and Clinical Immunology Department. Hospital São João. Porto. Portugal. danielamalheiro@hotmail.com

Allergologia Et Immunopathologia

|November 17, 2005

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Nimesulide, a nonsteroidal anti-inflammatory drug, can cause fixed drug eruptions, a type of skin reaction. This case highlights the importance of considering drug-induced eruptions in diagnosis.

Area of Science:

Pharmacology
Dermatology
Clinical Medicine

Background:

Nimesulide is a selective cyclooxygenase-2 inhibitor NSAID with analgesic and antipyretic properties.
Common side effects include gastrointestinal issues and cutaneous reactions like rash and pruritus.
Fixed drug eruptions (FDEs) are rare adverse reactions to nimesulide, with only eight prior cases reported.

Observation:

A patient with a history of antihistamine hypersensitivity developed a bullous, pigmented fixed drug eruption.
The eruption occurred subsequent to nimesulide ingestion.
Patch testing on residual lesions confirmed nimesulide as the causative agent.

Findings:

Nimesulide can induce bullous and pigmented forms of fixed drug eruptions.
Patch testing is a valuable diagnostic tool for identifying culprit drugs in FDEs.

Related Experiment Videos

This case adds to the limited literature on nimesulide-induced FDEs.

Implications:

Fixed drug eruptions are common but frequently misdiagnosed cutaneous drug reactions.
Thorough patient history and physical examination are crucial for suspecting FDEs.
Increased awareness of nimesulide's potential to cause FDEs is warranted for accurate diagnosis and management.