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Updated: Aug 14, 2026

Protein Isolation from the Developing Embryonic Mouse Heart Valve Region
Published on: September 23, 2014
Ras-related signaling pathways in valve development: ebb and flow
Katherine E Yutzey1, Melissa Colbert, Jeffrey Robbins
1Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Research Foundation, Ohio, USA.
Abstract:
Congenital heart defects affect approximately 1 in every 100 live births, and deficits in the formation of the mitral, tricuspid, and outflow tract valves account for 20-25% of all cardiac malformations. Mutations in genes that affect Ras signaling have been identified in individuals with congenital valve disease associated with Noonan syndrome and neurofibromatosis type 1. Dissection of Ras-related signaling pathways during valvulogenesis provides seminal insight into cellular and molecular mechanisms that contribute to congenital heart disease.
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