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Related Experiment Videos

Acid acclimation by Helicobacter pylori.

George Sachs1, David L Weeks, Yi Wen

  • 1Laboratory of Membrane Biology, David Geffen School of Medicine at the University of California-Los Angeles, USA. gsachs@ucla.edu

Physiology (Bethesda, Md.)
|November 17, 2005
PubMed
Summary
This summary is machine-generated.

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Helicobacter pylori colonizes the stomach using acid acclimation. This bacterium employs the UreI urea channel and periplasmic carbonic anhydrase to maintain a neutral periplasmic pH, enabling survival in acidic environments.

Area of Science:

  • Microbiology
  • Bacterial Physiology

Background:

  • Helicobacter pylori is a Gram-negative bacterium linked to peptic ulcers and gastric cancer.
  • Its ability to colonize the human stomach relies on acid acclimation mechanisms.

Purpose of the Study:

  • To elucidate the mechanisms by which Helicobacter pylori achieves acid acclimation and colonizes the stomach.
  • To understand the role of UreI and periplasmic carbonic anhydrase in bacterial survival.

Main Methods:

  • The study likely involved analyzing the function of the UreI protein and periplasmic carbonic anhydrase under acidic conditions.
  • Comparative analysis with other neutralophiles may have been employed.

Main Results:

  • Helicobacter pylori utilizes a pH-gated urea channel (UreI) for enhanced urea access to intrabacterial urease.

Related Experiment Videos

  • A membrane-anchored periplasmic carbonic anhydrase regulates periplasmic pH to approximately 6.1 in acidic environments.
  • Unlike other neutralophiles, H. pylori can maintain periplasmic pH, facilitating stomach colonization.

    • Conclusions:

    • Helicobacter pylori possesses unique adaptations for surviving and colonizing the acidic human stomach.
    • The coordinated action of UreI and periplasmic carbonic anhydrase is crucial for H. pylori's gastric niche establishment.