Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Plasma substitutes.

J Boldt1, S Suttner

  • 1Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt, Ludwigshafen, Germany. BoldtJ@gmx.net

Minerva Anestesiologica
|November 17, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retraction Note: Der neue Phosphodiesterasehemmer Enoximone: Einsatzmöglichkeiten im Rahmen herzchirurgischer Eingriffe.

Herz·2025
Same author

Retraction Note: Kolloidosmotischer Druck und extravaskuläres Lungenwasser nach extrakorporaler Zirkulation.

Herz·2025
Same author

Retraction Note: Alterations in circulating vasoactive substances in the critically ill-a comparison between survivors and non-survivors.

Intensive care medicine·2023
Same author

Retraction Note: The effects of pentoxifylline on circulating adhesion molecules in critically ill patients with acute renal failure treated by continuous veno-venous hemofiltration.

Intensive care medicine·2023
Same author

Retraction Note: Thrombomodulin in intensive care patients.

Intensive care medicine·2023
Same author

Retraction Note: Does long-term continuous administration of pentoxifylline affect platelet function in the critically ill patient?

Intensive care medicine·2023
Same journal

Rectus sheath block for analgesia in open abdominal surgery: a systematic review, meta-analysis and trial sequential analysis.

Minerva anestesiologica·2026
Same journal

Highlights from the June 2026 issue.

Minerva anestesiologica·2026
Same journal

Validation of the Gendolcat model for chronic postsurgical pain after cesarean section: a multicenter study.

Minerva anestesiologica·2026
Same journal

Dual block strategy for complex incision in pediatric kidney transplantation: M-TAPA and quadroiliac plane block combination.

Minerva anestesiologica·2026
Same journal

Technical note: a novel fully visualized, glottic-sparing strategy for infant one-lung ventilation.

Minerva anestesiologica·2026
Same journal

Ultrasound-guided recto-intercostal fascial plane block facilitating early extubation following pediatric subxiphoid pericardial window surgery.

Minerva anestesiologica·2026
See all related articles

Choosing the best fluid for volume replacement in critically ill patients is complex. Newer hydroxyethyl starch (HES) solutions show promise, but outcomes should be evaluated beyond mortality, considering organ function and inflammation.

Area of Science:

  • Critical Care Medicine
  • Pharmacology
  • Hemodynamics

Background:

  • Intravascular volume restoration is crucial for surgical, medical, and critically ill patients.
  • The choice between colloid and crystalloid solutions remains controversial.
  • The debate extends to different colloid types, including albumin and synthetic substitutes like hydroxyethyl starch (HES).

Purpose of the Study:

  • To review the controversies and evidence surrounding volume replacement strategies.
  • To compare the properties and efficacy of various plasma substitutes.
  • To discuss new perspectives on evaluating volume replacement beyond mortality.

Main Methods:

  • Review of existing literature on fluid resuscitation and plasma substitutes.
  • Analysis of pharmacokinetic, pharmacodynamic, hemodynamic, and side-effect profiles of different solutions.

Related Experiment Videos

  • Discussion of emerging concepts in critical care relevant to volume management.

    • Main Results:

    • Hydroxyethyl starch (HES) preparations vary significantly in properties and efficacy.
    • Newer HES generations (e.g., 6% HES 130/0.4) may offer improved therapeutic potential.
    • Albumin is costly, and dextrans have adverse effects; neither is recommended for routine hypovolemia correction.

    Conclusions:

    • Volume replacement strategies require re-evaluation beyond simple mortality metrics.
    • Organ perfusion, organ function, inflammation, and immunological aspects are critical considerations.
    • Further well-designed studies are needed to establish optimal volume replacement strategies for hypovolemic patients.