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The ROC analysis for different time points during oral glucose tolerance test
Weibin Zhou1, Hong Li, Yanyun Gu
1Shanghai Institute of Endocrinology, Department of Endocrinology, Ruijin Hospital, Shanghai Second Medical University, 197 Ruijin 2nd Road, Shanghai 200025, China. pdsucs@163.com
Diabetes Research and Clinical Practice
|November 18, 2005
Summary
This study establishes optimal reference values for normal glucose tolerance (NGT) during an oral glucose tolerance test (OGTT) using receiver operating characteristic (ROC) analysis. These findings provide crucial benchmarks for evaluating glucose regulation status in diverse populations.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Clinical Diagnostics
Background:
- Accurate assessment of glucose metabolism is vital for diagnosing diabetes and related disorders.
- Establishing reliable reference ranges for normal glucose tolerance (NGT) is essential for clinical interpretation of oral glucose tolerance tests (OGTT).
- Existing NGT criteria may require refinement to account for population-specific variations and diagnostic accuracy.
Purpose of the Study:
- To determine optimal reference values for normal glucose tolerance (NGT) at various time points during an oral glucose tolerance test (OGTT).
- To utilize receiver operating characteristic (ROC) analysis to establish these reference values based on established diagnostic criteria.
- To provide age-stratified reference ranges to account for demographic differences in glucose metabolism.
Main Methods:
- Recruited 1,746 subjects for a 75g OGTT with blood sampling at 0, 30, 60, 120, and 180 minutes.
- Classified subjects into normal glucose tolerance (NGT), impaired glucose tolerance (IGT), impaired fasting glucose (IFG), and diabetes mellitus (DM) based on American Diabetes Association (ADA) criteria.
- Merged IGT and IFG into impaired glucose regulation (IGR) and employed ROC analysis to derive cutoff values for NGT reference ranges.
Main Results:
- Established specific cutoff values for NGT at 0, 30, 60, 120, and 180 minutes: 5.6, 9.5, 10.1, 7.8, and 6.1 mmol/l, respectively, for the overall cohort.
- Provided age-stratified ROC information, highlighting differences in glucose tolerance across age groups.
- The study offers a validated reference range for assessing glucose tolerance status via OGTT results.
Conclusions:
- The study successfully defined optimal reference values for normal glucose tolerance during OGTT using ROC analysis.
- These reference values offer improved accuracy in evaluating glucose regulation status.
- Further research is recommended to address the heterogeneity of diabetes and refine diagnostic criteria, with ongoing sample collection.